Think about prescribing naloxone, based on the affected individual’s risk things for overdose, which include concomitant usage of CNS depressants, a heritage of opioid use disorder, or prior opioid overdose. The existence of danger elements for overdose mustn't reduce the right management of soreness in almost any given client. Also look at prescribing naloxone If your client has home customers (like youngsters) or other shut contacts in danger for accidental ingestion or overdose.
Inform patients to prevent using oxycodone and acetaminophen tablets though working with any medicines that inhibit monoamine oxidase. Individuals shouldn't commence MAOIs while having oxycodone and acetaminophen tablets [see PRECAUTIONS; DRUG INTERACTIONS].
Acetaminophen has been associated with circumstances of acute liver failure, occasionally causing liver transplant and death.
Rapid discontinuation has also been affiliated with makes an attempt to seek out other sources of opioid analgesics, which can be puzzled with drug-looking for for abuse. Clients can also try to address their suffering or withdrawal signs and symptoms with illicit opioids, which include heroin, and other substances.
These consequences look to raise While using the length of procedure. The medical importance of these results is not really recognised.
Speedy discontinuation has also been associated with attempts to locate other sources of opioid analgesics, which may be confused with drug-searching for for abuse.
Although the risk of habit in any person is unknown, it may possibly manifest in individuals correctly prescribed PERCOCET. Dependancy can happen at advisable dosages and In the event the drug is misused or abused.
For the duration of pregnancy, this medication should be used only when Plainly needed. It could hurt an unborn newborn. Go over the hazards and Gains with all your medical professional.
Because the utilization of PERCOCET exposes clients and other buyers to the pitfalls of opioid addiction, abuse, and misuse, which can cause overdose and Loss of life, evaluate Each individual client’s read more chance just before prescribing and reassess all clients routinely for the event of those behaviors and ailments [see WARNINGS].
In people having opioids for an prolonged time period at large doses, ensure that a multimodal approach to suffering management, which include psychological overall health aid (if needed), is in position previous to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION and WARNINGS].
Accidental ingestion of even a single dose of PERCOCET, especially by children, can result in respiratory despair and death due to an overdose of oxycodone.
To cut back the potential risk of dizziness and lightheadedness, get up slowly when climbing from the sitting or lying situation.
Mutagenesis The mix of Oxycodone Hydrochloride and Acetaminophen hasn't been evaluated for mutagenicity. Oxycodone alone was adverse in a bacterial reverse mutation assay (Ames), an in vitro chromosome aberration assay with human lymphocytes devoid of metabolic activation and an in vivo mouse micronucleus assay.
In sufferers who can be susceptible to the intracranial results of CO2 retention (e.g., Individuals with evidence of enhanced intracranial stress or brain tumors), oxycodone and acetaminophen tablets could lessen respiratory travel, along with the resultant CO2 retention can even more raise intracranial force.